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Polynucleotides in Aesthetic Practice: A Revolutionary Skincare Approach 
In the realm of aesthetic medicine, solutions to achieve a youthful glow are continually evolving. One such revolutionary approach that’s creating a buzz is the use of polynucleotides. Before delving into its benefits and comparison with hyaluronic acid-based product, let’s first understand what they are.

Understanding Polynucleotides 
Polynucleotides (PN’s) are essentially long chains of nucleotides. Nucleotides are the building blocks of DNA and RNA, and they play a crucial role in cellular repair and regeneration. When applied in aesthetics, specifically in topical skincare products and injectables, they stimulate skin healing, hydration, and rejuvenation.

Benefits of Polynucleotides in Aesthetic Practice
One of the key benefits of polynucleotides is their hydrating effect. They are known for their excellent water-binding capacity, making them an ideal solution for dehydrated skin.

Using PN’s in aesthetics also helps stimulate regeneration of the skin’s dermal structure. They accelerate the synthesis of collagen and elastin, leading to a reduction in fine lines and wrinkles, and improving skin elasticity and firmness.

Moreover, they have anti-inflammatory properties which aids in reducing redness and skin inflammation, making them ideal for sensitive skin.

Comparison with Hyaluronic Acid-based Products
Hyaluronic acid has been a gold standard ingredient in aesthetic skincare for years. It’s known for its unparalleled ability to attract and retain moisture in the skin. While hyaluronic acid provides instant plumping and hydrating effects, PNs provide a more long term and sustainable effect. They not only hydrate but also repair and regenerate skin from within. This, in essence, means that PNs not only provide immediate visible results, they also contribution to lasting skin health.

How to Use Polynucleotides in Aesthetics
Polynucleotides can be applied topically, as a high-quality skincare product or through medical needling or injections performed by a trained aesthetician or cosmetic doctor. These procedures stimulate natural collagen and elastin production, leading to skin rejuvenation over time.

Top Polynucleotide Products in the UK Market
It’s worth noting that the efficacy of PN’s will significantly depend on the individual product. Below are some of the top PN products available in the UK market:

Plinest stands out with its polynucleotides derived from trout fish. It addresses a broad spectrum of skin concerns, effectively targeting fine lines, wrinkles, volume loss, and is also suitable for sensitive skin. Plenist is beneficial in reducing acne scars, hyperpigmentation, and refining enlarged pores.

Plenhyage utilises salmon-derived polynucleotides and is renowned for its hydrating properties, as well as its ability to improve lines, wrinkles, and provide a lifting effect. It is particularly effective for treating hollow eyes, dehydrated skin, and stretch marks. The treatment involves a series of four sessions, with results typically becoming visible three months after the course is completed.

Nucleofill focuses on skin renewal and bio-restructuring derived from salmon DNA. It offers lifting, antioxidant, and moisturising benefits, stimulating cell renewal and collagen production. This makes it suitable for skin affected by oxidative stress, dehydration, stretch marks, and scars.

Vitaran is a 100% quality-controlled polynucleotide injectable derived from purified salmon DNA. It is a bio-revitalising skin injectable with anti-inflammatory properties, stimulating the synthesis of collagen, elastin, and hyaluronic acid. Vitaran is particularly effective for skin rejuvenation and repair, scar improvement, and combating free radical damage.

In conclusion, the use of polynucleotides in aesthetics is a game-changer, combining the benefits of immediate and long-term skin enhancement. As with any skin treatment, it’s vital to consult with a professional aesthetician before introducing them into your skincare regimen.


Please note that while purchasing aesthetic products online, it’s vitally important to ensure the credibility of suppliers. Always go to trusted platforms and read reviews before making a purchase. For aesthetic treatments that involve injections, it is strongly advised to consult with a professional aesthetician or cosmetic doctor. Ensure these are administered by trained personnel in a clinical setting to guarantee safety and efficacy.

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